Breakthrough Discovery for Malaria and Covid-19 Treatment

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Recent research from Jawaharlal Nehru University (JNU) has revealed findings that could enhance treatments for malaria and Covid-19. Scientists discovered the very important role of the human protein Hsp70 in the spread of these diseases. This work involved collaboration between Indian and Russian researchers.

About Hsp70

Hsp70, or Heat Shock Protein 70, is crucial for protein folding, which prevents misfolding and maintains cellular health. This protein is essential for various biological processes, including the response to stress.

The Role of Hsp70 in Infections

The research indicates that Hsp70 interacts with the spike protein of the SARS-CoV-2 virus and the human ACE2 receptor. This interaction facilitates viral entry into cells. Elevated Hsp70 levels during fever may enhance the virus’s infectivity.

Development of Hsp70 Inhibitors

Researchers developed a small molecule inhibitor of Hsp70, named PES-Cl. This inhibitor was tested on cells infected with SARS-CoV-2. Results showed complete viral inhibition at low doses, indicating its potential as a treatment.

Advantages of Targeting Host Proteins

Targeting Hsp70, a host protein, reduces the likelihood of drug resistance. Viruses like SARS-CoV-2 can rapidly mutate. This approach may effectively combat such fast-evolving pathogens.

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